Libera me, Domine, de morte aeterna
For the world where death never comes
This page compiles various items with potential anti-aging effects. It is not exhaustive, and I plan to expand it over time. Implementing these practices and supplements is at your own risk, and it's wise to consult with a physician first:
- Green tea is rich in polyphenols that are strong antioxidants, able to destroy free radicals and help slow down the aging process. Drinking and applying green tea helps to fight skin cancer by promoting the repair of DNA damage caused by UV rays.
- Yerba mate contains high levels of phytochemical antioxidants in far greater quantities than in green tea. Like green tea, it has anti-cancer and anti-aging benefits.
- Curcumin, a polyphenol, available in the plant Curcuma (turmeric) shows possible anti-aging effects. Contained in a diet, it extended the lifespan of fruit flies, nematodes, and mice. In clinical trials, curcumin was proven to reduce symptoms of some age-related diseases such as atherosclerosis, diabetes, and cancer. It also serves as a neuroprotective agent and it should also be able to protect against chemotherapy-induced side effects.
- Olive oil has been shown to cut the risk of heart disease and slows cognitive decline. It is good for the skin, hair, and nails. The recommended daily dose is 3 tablespoons (3x 11 grams).
- Caffeine can be also helpful in increasing longevity. Mainly thanks to its contribution to inflammation blocking according to some studies. Recommended is max. 4 cups per day (one standard cup is 8.3 grams of coffee/1.6 teaspoons), more can lead to an increased risk of premature death. The last coffee should be drank max. 6 hours before sleep - otherwise, there is a possibility of an unobservable sleep disturbance.
Generally, coffee consumption reduces the risk of hepatocellular carcinoma (HCC), the most common type of liver cancer, by about 40 percent.
2 cups of coffee a day = 10 percent reduction in premature death
3 cups of coffee a day = reducing the risk of liver cancer by more than 50 percent
More than 28 cups of coffee per week (4 per day) = increases the risk of premature death in people under 55. Younger men have an increased risk of up to 56% and younger women are doubled.
- Capsaicin, contained in chili peppers, seems to be helpful also in lifespan extending, among other health benefits. Eating chili peppers can lead to a 13% reduction in mortality - mainly in cases related to cardiovascular diseases and strokes.
Supplements
- Higher concentrations of vitamin D, which can be easily modified by nutritional supplements, are associated with longer telomeres, and thus with the potentially beneficial effects of this vitamin on slowing down aging and suppressing age-related diseases. In addition, it can also strengthen the immune system and is associated with a reduced risk of colon and breast cancer. It also helps with weight loss and bone strengthening.
- Omega-3 fatty acids can help slow down a key biological process associated with aging - telomere shortening. They can also reduce oxidative stress caused by excessive free radicals in the blood.
- Lecithin generally promotes the good health of the elderly. Its application can improve the state of cognitive functions in the elderly. It supports cardiovascular health, can lower diastolic blood pressure and also lower bad LDL cholesterol, and help raise good HDL cholesterol. Lack of lecithin in the body can increase the risk of atherosclerosis and hardening of the arteries. On the contrary, 1200 mg of lecithin per day is said to rejuvenate the vascular system by up to 10 years. It also helps fight hearing loss associated with aging.
- Ginkgo Biloba also has anti-aging effects. Its long-term use can reduce cardiovascular risks and also improve the cognitive functions of patients with Alzheimer's disease.
- Ginseng can reduce oxidative stress and reduce oxidative damage. It helps reduce the risk of cardiovascular disease and has a positive effect on the nervous system and motor functions. It has a rejuvenating effect on the skin as well as immunoregulatory and anti-inflammatory effects.
- Coenzyme Q10 is an antioxidant that acts as a prevention of chronic oxidative stress associated with cardiovascular and neurodegenerative diseases. The effects of long-term consumption (200 mg/day) together with selenium (200 μg as selenized yeast) in the Swedish healthy elderly population showed a significant reduction in cardiovascular mortality not only during the first 4 years of consumption but also 10 years later. It can also reduce the side effects of statins, thus preventing or slowing the progression of fragility and sarcopenia in the elderly chronically treated with statins. Short-term daily treatment (12 weeks or less) of 100 mg daily improves left ventricular ejection fraction in patients with heart failure.
- One study found taking aspirin for 10 years can cut bowel cancer by 35% and reduce death rates in cancer patients. Taking daily NSAIDs, including aspirin or ibuprofen, was also associated with large reductions in cancer including 63% for the colon, 73% for esophageal, and 62% for the stomach. Another review determined a daily small dose of Aspirin could reduce overall cancer risk by 25%. Ibuprofen extends the lifespan in model organisms by about 20%, and aspirin has shown life-extending effects too. Research has also found Ibuprofen reduces the risk of Parkinson's disease by 30%.
Unfortunately, aspirin has its contraindications as well (for example, it can increase the risk of gastrointestinal bleeding), so it should not be consumed as a normal diet supplement.
- Resveratrol contained in red wine does provide anti-aging benefits. A study shows that Resveratrol stimulates the production of SIRT1, a serum that blocks diseases by speeding up the cell's energy production centers known as mitochondria. Resveratrol has been linked to protection against obesity and diabetes, a reduced risk for blood clotting, and a way to lower "bad" LDL cholesterol.
- There are more than 800 published studies documenting the ability of Piracetam to promote youthful neurologic function. It is also the most frequently used drug to boost short-term memory and overall cognitive function.
Other
- Nicotinamide riboside (NR) vitamin can stimulate the regeneration of lost muscle tissue in elderly mice, and it is also increasing their lifespan. The vitamin is involved in processes related to the healthy functioning of mitochondria. The mice were able to generate larger numbers of muscle stem cells after receiving NR, which later developed into adult muscle cells and led to enhanced muscular strength and function. The mice that had received NR also lived longer than those that had not been treated with the vitamin. The study authors observed no negative side effects, even when feeding mice with high doses of NR.
- Fasting could prevent aging. Studies have shown that reducing typical calorie consumption, usually by 30 to 40 percent, extends the life span by a third or more in many animals. When it comes to calorie restriction in primates and people, however, the jury is still out. Although some studies have suggested that monkeys that eat less live longer, a new 25-year-long primate study concluded that calorie restriction does not extend the average life span in rhesus monkeys. Even if calorie restriction does not help to live longer, a large portion of the data supports the idea that limiting food intake reduces the risks of diseases common in old age and lengthens the period of life spent in good health.
- Yerba mate contains high levels of phytochemical antioxidants in far greater quantities than in green tea. Like green tea, it has anti-cancer and anti-aging benefits.
- Curcumin, a polyphenol, available in the plant Curcuma (turmeric) shows possible anti-aging effects. Contained in a diet, it extended the lifespan of fruit flies, nematodes, and mice. In clinical trials, curcumin was proven to reduce symptoms of some age-related diseases such as atherosclerosis, diabetes, and cancer. It also serves as a neuroprotective agent and it should also be able to protect against chemotherapy-induced side effects.
- Olive oil has been shown to cut the risk of heart disease and slows cognitive decline. It is good for the skin, hair, and nails. The recommended daily dose is 3 tablespoons (3x 11 grams).
- Caffeine can be also helpful in increasing longevity. Mainly thanks to its contribution to inflammation blocking according to some studies. Recommended is max. 4 cups per day (one standard cup is 8.3 grams of coffee/1.6 teaspoons), more can lead to an increased risk of premature death. The last coffee should be drank max. 6 hours before sleep - otherwise, there is a possibility of an unobservable sleep disturbance.
Generally, coffee consumption reduces the risk of hepatocellular carcinoma (HCC), the most common type of liver cancer, by about 40 percent.
2 cups of coffee a day = 10 percent reduction in premature death
3 cups of coffee a day = reducing the risk of liver cancer by more than 50 percent
More than 28 cups of coffee per week (4 per day) = increases the risk of premature death in people under 55. Younger men have an increased risk of up to 56% and younger women are doubled.
- Capsaicin, contained in chili peppers, seems to be helpful also in lifespan extending, among other health benefits. Eating chili peppers can lead to a 13% reduction in mortality - mainly in cases related to cardiovascular diseases and strokes.
Supplements
- Higher concentrations of vitamin D, which can be easily modified by nutritional supplements, are associated with longer telomeres, and thus with the potentially beneficial effects of this vitamin on slowing down aging and suppressing age-related diseases. In addition, it can also strengthen the immune system and is associated with a reduced risk of colon and breast cancer. It also helps with weight loss and bone strengthening.
- Omega-3 fatty acids can help slow down a key biological process associated with aging - telomere shortening. They can also reduce oxidative stress caused by excessive free radicals in the blood.
- Lecithin generally promotes the good health of the elderly. Its application can improve the state of cognitive functions in the elderly. It supports cardiovascular health, can lower diastolic blood pressure and also lower bad LDL cholesterol, and help raise good HDL cholesterol. Lack of lecithin in the body can increase the risk of atherosclerosis and hardening of the arteries. On the contrary, 1200 mg of lecithin per day is said to rejuvenate the vascular system by up to 10 years. It also helps fight hearing loss associated with aging.
- Ginkgo Biloba also has anti-aging effects. Its long-term use can reduce cardiovascular risks and also improve the cognitive functions of patients with Alzheimer's disease.
- Ginseng can reduce oxidative stress and reduce oxidative damage. It helps reduce the risk of cardiovascular disease and has a positive effect on the nervous system and motor functions. It has a rejuvenating effect on the skin as well as immunoregulatory and anti-inflammatory effects.
- Coenzyme Q10 is an antioxidant that acts as a prevention of chronic oxidative stress associated with cardiovascular and neurodegenerative diseases. The effects of long-term consumption (200 mg/day) together with selenium (200 μg as selenized yeast) in the Swedish healthy elderly population showed a significant reduction in cardiovascular mortality not only during the first 4 years of consumption but also 10 years later. It can also reduce the side effects of statins, thus preventing or slowing the progression of fragility and sarcopenia in the elderly chronically treated with statins. Short-term daily treatment (12 weeks or less) of 100 mg daily improves left ventricular ejection fraction in patients with heart failure.
Unfortunately, aspirin has its contraindications as well (for example, it can increase the risk of gastrointestinal bleeding), so it should not be consumed as a normal diet supplement.
- Resveratrol contained in red wine does provide anti-aging benefits. A study shows that Resveratrol stimulates the production of SIRT1, a serum that blocks diseases by speeding up the cell's energy production centers known as mitochondria. Resveratrol has been linked to protection against obesity and diabetes, a reduced risk for blood clotting, and a way to lower "bad" LDL cholesterol.
- There are more than 800 published studies documenting the ability of Piracetam to promote youthful neurologic function. It is also the most frequently used drug to boost short-term memory and overall cognitive function.
Other
- Nicotinamide riboside (NR) vitamin can stimulate the regeneration of lost muscle tissue in elderly mice, and it is also increasing their lifespan. The vitamin is involved in processes related to the healthy functioning of mitochondria. The mice were able to generate larger numbers of muscle stem cells after receiving NR, which later developed into adult muscle cells and led to enhanced muscular strength and function. The mice that had received NR also lived longer than those that had not been treated with the vitamin. The study authors observed no negative side effects, even when feeding mice with high doses of NR.
- Fasting could prevent aging. Studies have shown that reducing typical calorie consumption, usually by 30 to 40 percent, extends the life span by a third or more in many animals. When it comes to calorie restriction in primates and people, however, the jury is still out. Although some studies have suggested that monkeys that eat less live longer, a new 25-year-long primate study concluded that calorie restriction does not extend the average life span in rhesus monkeys. Even if calorie restriction does not help to live longer, a large portion of the data supports the idea that limiting food intake reduces the risks of diseases common in old age and lengthens the period of life spent in good health.
- Metformin, a drug that is widely used to treat diabetes, has already been demonstrated to slow the aging process in certain microbes and mammals. It could - based on these studies — extend the human lifespan by up to 40 percent and decrease the chances of getting age-related diseases.
- Rapamycin - After nearly a decade of research showing that it makes mice live up to 60% longer, scientists are trying it out as an anti-aging drug in dogs and humans. It can lengthen the lives of old mice by 9 to 14 percent, and it boosts longevity in flies and yeast too. On the other hand, it strongly suppresses the immune system and increases the risk of diabetes.
- Blood from human teenagers helps to rejuvenate the body and brains of old mice. So far, there is also a study that disproves this approach, saying that there is a different underlying process.
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